By Miroslaw Janowski

This quantity presents an entire rationalization and technical info to accomplish surgical recommendations correctly on small and massive animal types. the 1st six chapters of Experimental Neurosurgery in Animal Models concentration totally on the mind, whereas the following six chapters main issue the spinal twine in rodents. The final 4 chapters offer an outline of operative techniques in huge animals. Written for the preferred Neuromethods series, chapters comprise the type of aspect and key implementation recommendation that guarantees profitable leads to the laboratory.

Authoritative and practical, Experimental Neurosurgery in Animal Models aims to make certain profitable ends up in the extra research of this very important field.

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20. Anesthesia reversal is given and endotracheal tube is removed once animal starts breathing on her own. 21. Animal is placed in the cage and monitored till she is fully awake and active. 2 Animal Observation Protocol 1. All animals are observed daily to monitor external appearance, feeding behavior, and locomotion (ability to walk to a distance of 50 cm in 10 s). 2. The contralateral limbs are observed daily for the development of paresis both passively and actively. 3. Depending upon the goals of research follow-up MR imaging is performed.

The stereotactic MR images using an FOV (field of view) of 250 × 250 mm are obtained using standard head coil. 26 Ajay Niranjan et al. 9. The images are transferred to Gammaplan computer via ethernet system. 10. Stereoatctic images are defined using GammaPlan software. 11. The target is selected based on the goals of the experiment. The target could be thalamus, trigeminal nerve, caudate nucleus, hypothalamus, etc. 12. An optimum margin and central dose is selected. 13. The plan is printed and exported to Leksell Gamma unit.

A central dose of 80 or 100 Gy using a 4 mm collimator was delivered to the normal proximal trigeminal nerve. Follow-up MRI at 6 months showed a 4 mm region of contrast enhancement on the nerve. Histology showed that both large and small fibers were affected with axonal degeneration occurring after 80 Gy and necrosis after 100 Gy. Neither dose was effective at selectively damaging fibers responsible for transmission of pain while maintaining those responsible for other sensations, which would be optimal for effective treatment of trigeminal neuralgia.

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