By G. C. Barrett

This article is meant for undergraduate and starting graduate scholars in chemistry and biochemistry learning amino acids and peptides. The authors be aware of amino acids and peptides with no distinctive discussions of proteins, whereas giving all of the crucial heritage chemistry, together with series choice, synthesis and spectroscopic equipment. The method is meant to inspire the reader to move classical barriers whereas gaining an realizing of protein habit on a molecular point. The publication comprises chapters at the organic roles of amino acids, in addition to a piece on enzyme-catalyzed synthesis of peptides, with appropriate examples, a space usually missed in texts describing peptide synthesis. this contemporary textual content could be of worth within the amino acid, peptide and protein box, to complicated undergraduates, graduate scholars and study staff.

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Extra resources for Amino Acids and Peptides (1998)

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This amino acid betaine is sometimes called ‘vitamin BT’ and plays a part in the conversion of stored body fat into energy, through transport of fat molecules of high relative molecular mass to the sites of their conversion. The (2R,3S)-phenylisoserine side-chain at position 13 of the taxane skeleton in the anti-cancer drug taxol (from the yew tree) is essential to its action. 14 References Reviews providing information on all aspects of amino-acid science (Barrett, 1985; Greenstein and Winitz, 1961; Williams, 1989) and peptide chemistry (Jones, 1991) are listed at the end of the Foreword.

4) and replacement of this by its N-methyl analogue, or similar replacement of residue 3 (-valine), leads to distorted helical sequences from residues 2–8, as shown by circular dichroism (CD) measurements, which leads in turn to the change-over from the natural quaternary structure (dimeric for bovine zinc insulin) to the monomeric form. It is not surprising, bearing in mind the substantial conformational changes accompanying apparently insignificant structural changes, that these analogues show only about 12% of the potency of the natural hormone, according to radioimmunoassay evidence (Chapter 4).

1996) Circular Dichroism in Conformational Analysis of Biomolecules, Plenum, New York. Hermkens, P. H. , van Dinther, T. , Joukema, C. , Wagenaars, G. N. and Ottenheijm, H. C. , 35, 9271. , Buttkus, U. -H. (1991) Angew. Chem. Int. , 30, 1514. Zimm, B. , and Bragg, J. K. (1959) J. Chem. , 31, 526. g. g. g. aliphatic hydroxy and side-chain amide groups). The properties of peptides also depend on the same factors, but it must be remembered that, in a linear peptide containing n amino-acid residues, all but one ␣-amino group and one ␣carboxy group are incorporated into neutral peptide and amide bonds.

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