By Dale J. Benos (Eds.)

Sodium reabsorbing epithelia play an incredible function in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium delivery throughout those membranes is a two-step method: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for shipping and are regulated via a number of various hormones. The sodium channels additionally play an important function in a few illness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful range offers the 1st in-depth alternate of rules relating those sodium channels, their rules and involvement in general and pathophysiological events. Key beneficial properties * Summarizes present nation of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal law of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * offers rules on sodium channels and affliction

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Extra resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

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Reprinted with permission from Fuller et al, (1997). 1. StructureFunction in LybENaC a- bENaC 17 WT .. a- bENaC K515E a- bENaC K504E Time (min) ... 18 C. M. Fuller et al. ,,/ 100 mM FIGURE 7 Currentlvoltage relationship and ion selectivity for wild-type, K504E, and K515E abENaC. The current/voltage relations for wt abENaC and K504E and K515E abENaC are shown on the top panel. Neither mutation affected single-channel conductance recorded under symmetrical conditions. The ion selectivity of wild-type and mutant ENaC subunits was determined under bi-ionic conditions, with 100 mM Na+ in the trans compartment and 100 mM K+ in the cis chamber, and is shown in the bottom panel.

1995). Alternatively spliced forms of the a subunit of the epithelial sodium channel: Distinct sites for amiloride binding and channel pore. Mol. Pharmncol. 47, 1133-1140. , and Barbry, P. (1995). Cloning of the amiloridesensitive FMRFamide peptide-gated sodium channel. Nature (London) 378, 730-733. , and Eaton, D. C. (1991). Effects of vasopressin and CAMPon single amilorideblockade Na channels. Am. J. Physiol. 260, C1071-C1084. Oh, Y . , Smith, P. R.. Bradford, A. , and Benos, D. J. (1993). Regulation by phosphorylation of purified epithelial Na channels in planar lipid bilayers.

Fuller, C. , Achard, J. , Benos, D. , and U'arnock, D. G . (1996). Liddle's disease: Abnormal regulation of amiloride-sensitive Na' channels by p-subunit mutation. Am. J. Physiol. 270, C208-C213. Canessa, C. , and Rossier, B. C. (1993). Epithelial sodium channel related to proteins involved in neurodegeneration. Nature (London) 361,467-470. Canessa, C. , and Rossier, B. C. (1994a). Membrane topology of the epithelial sodium channel. Am. J. fhysiol. 267, C1682-Cl690. Canessa, C. , and Rossier, B.

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