By Steven Specter (auth.), Steven Specter (eds.)

In Viral Hepatitis: prognosis, treatment, and Prevention, top foreign virologists evaluation the state of the art within the biology, pathogenesis, and epidemiology of the hepatitis viruses. The specialists writing the following learn the 5 well-recognized hepatitis viruses, A via E, and a few of the more recent brokers, the so-called non A-E hepatitis viruses. in addition they offer in-depth discussions of the biology of the viruses, the pathogenesis of the intense and persistent ailments they reason, the equipment and straightforwardness with which they're transmitted, and their medical symptoms. extra subject matters contain diagnostic exams and regimen blood screening, new vaccines, and using interferon and antiviral medicines.
Viral Hepatitis: analysis, treatment, and Prevention offers the main entire and up to date survey of the hepatitis viruses presently on hand. wealthy within the sensible info of viral analysis, therapy, and prevention, it constitutes modern day gold-standard reference in this significant well-being risk for all involved physicians and researchers.

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Extra info for Viral Hepatitis: Diagnosis, Therapy, and Prevention

Sample text

1. Genetic map of HBV, showing the four open-reading frames and the two major transcripts. The minor preSl and X transcripts are not shown. DRl and DR2 refer to direct repeat 1 and direct repeat 2. (Courtesy of Dr. ) protein has, in addition, to the pre-S2 domain, a 119 or 108 residue (depending on subtype) N -terminal extension called the pre-S 1 domain. 2 kb in length. Unique among animal virus families, the viral DNA is a partially double-stranded circular molecule, with the viral polymerase protein covalently attached to the 5' end of one strand.

102. , Lemon, S. , and Wychowski, C. (1995) Identification and site-directed mutagenesis of the primary (2A12B) cleavage site of the hepatitis A virus polyprotein: functional impact on the infectivity of HAV RNA transcripts. Virology 213, 213-222. 103. Mathiesen, L. R, Feinstone, S. , Wong, D. , and Purcell, R H. (1978) Enzyme-linked immunosorbent assay for detection of hepatitis A antigen in stool and antibody to hepatitis A antigen in sera: comparison with solid-phase radioimmunoassay, immune electron microscopy, and immune adherence hemagglutination assay.

The role, if any, of these other forms of X protein during natural infection is unknown and can only be clarified by studies of additional X mutants in woodchucks. 5. Genome Replication After encapsidation of the pregenomic RNA by the polymerase and core proteins, reverse transcription of the RNA commences.

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