By W. Jelkmann, A. J. Gross (auth.), Professor Dr. med. Wolfgang Jelkmann, Dr. med. Andreas J. Gross (eds.)

The booklet features a sequence of updated assessment articles at the body structure and pathophysiology of the keep watch over of the creation of crimson cells through the hormone erythropoietin. additionally, the consequences are pronounced of preliminary medical trials utilizing recombinant human erythropoietin (rhuEpo) within the therapy of the anemia of renal failure. The introductory bankruptcy in short remembers the historical past of erythropoietin study. the next part at the chemistry and body structure covers info of the constitution of the hormone, assay tools, the identity of renal and extrarenal websites of the construction of erythropoietin by means of in situ hybridization and the hypoxic stimulation of its creation. a unique bankruptcy is dedicated to the rules of erythropoiesis within the neonatal interval. There follows a piece on pathophysiology, together with respiration, renal and malignant ailments in people. within the ultimate part the pharmacology of rhuEpo is taken into account. the method of the cloning and in vitro expression of the erythropoietin gene is defined. 4 chapters summarize scientific observations of the consequences of rhuEpo within the correction of the anemia of renal failure, together with the increase in hematocrit, blood viscosity and doubtless high blood pressure, and the elevated actual paintings skill of the sufferers. The monograph will end up helpful not just to investigators operating within the easy fields of body structure, pharmacology and endocrinology, but additionally to training physicians, particularly hematologists and nephrologists, who're drawn to erythropoietin for diagnostic or healing reasons.

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Goldwasser E (1987) The molecular biology of erythropoietin and the expression of its gene. In: Rich IN (ed) Molecular and cellular aspects of erythropoietin and erythropoiesis. Springer, Berlin Heidelberg New York, pll (NATO ASI series, vol 8) 5. Caro J, Schuster S, Besarab A, Erslev AJ (1987) Renal biogenesis of erythropoietin. In: Rich IN (ed) Molecular and cellular aspects of erythropoietin and erythropoiesis. Springer, Berlin Heidelberg New York, p 329 (NATO ASI series, vol 8) 6. Nishida J, Hirai H, Kubota M, Lin F-K, Okabe T, Urabe A, Takaku F (1986) Detection of erythropoietin message in hypoxic mouse kidney.

44 H. Pagel, W. Jelkmann, and C. Weiss References 1. Abbrecht PH, Littell JK (1972) Plasma erythropoietin in men and mice during acclimatization to different altitudes. J Appl Physiol 32: 54-58 2. Alexanian R (1973) Erythropoietin excretion in bone marrow failure and hemolytic anemia. J Lab Clin Med 82: 438-445 3. Bacon BR, Rothman SA, Ricanati ES, Rashad FA (1980) Renal artery stenosis with erythrocytosis after renal transplantation. Arch Intern Med 140: 1206--1211 4. Barcelo AC, Bozzini CE (1982) Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection.

Erslev AJ, Caro J, Kansu E, Silver R (1980) Renal and extrarenal erythropoietin production in anaemic rats. Br J Haematol45: 65-72 16. Erslev AJ, Caro J, Miller 0, Silver R (1980) Plasma erythropoietin in health and disease. Ann Clin Lab Sci 10: 250-257 17. Erslev AJ, Wilson J, Caro J (1987) Erythropoietin titers in anemic, nonuremic patients. J Lab Clin Med 109: 429-433 18. Faura J, Ramos J, Reynafarje C, English E, Finne P, Finch CA (1969) Effect of altitude on erythropoiesis. Blood 33: 668--676 19.

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