By Robert A. Bonomo, Marcelo E. Tolmasky

Antibiotic-resistant micro organism, or "superbugs," current an more and more lethal hazard to human healthiness. With chapters from the world's prime researchers and students during this box, this entire quantity is a crucial and well timed evaluate of this severe subject.


This e-book offers a state of the art evaluation of the mechanisms of resistance. The enzymes and enzyme platforms distinctive during this paintings contain these enthusiastic about genetic reorganization, antibiotic Read more...

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Extra resources for Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition

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44. Ogle, J. , D. E. Brodersen, W. M. Clemons, M. J. Tarry, A. P. Carter, and V. Ramakrishnan. 2001. Recognition of cognate transfer RNA by the 30S ribosomal subunit. Science 292:897–902. 45. , and Y. Suzuki. 1965. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome ‘R’. Nature 208:1301–1303. 46. , D. Gur, S. Unal, and G. H. Miller. 2001. The changing nature of aminoglycoside resistance mechanisms and prevalence of newly recognized resistance mechanisms in Turkey.

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Sherratt, and M. E. Tolmasky. 2003. The aminoglycoside 6p-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell’s cytoplasm. Antimicrob. Agents Chemother. 47:2897–2902. Donabedian, S. , L. A. Thal, E. Hershberger, M. B. Perri, J. W. Chow, P. Bartlett, R. Jones, K. Joyce, S. Rossiter, K. Gay, J. Johnson, C. Mackinson, E. Debess, J. Madden, F. Angulo, and M. J. Zervos. 2003. Molecular characterization of gentamicin-resistant enterococci in the United States: evidence of spread from animals to humans through food.

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