By Christopher Power, Richard T. Johnson
Providing a transparent and authoritative assessment of contemporary advancements in microbiology and neuroscience, this reference describes elements contributing to the emergence and resurgence of neurological infections-studying either new and drug-resistant pathogens, in addition to long term prevention and regulate innovations for those illnesses.
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Extra info for Emerging Neurological Infections (Neurological Disease and Therapy)
Viruses resistant to inhibitors occur at high frequencies, mainly for RNA viruses (Sec. 5).
These complex effects of population size on viral fitness are summarized in Fig. 4. Microbial Evolution and Emerging Diseases 17 2. Viruses may maintain a memory of their past evolutionary history in the form of minority genomes present in their mutant spectra. Work with the important animal pathogen FMDV has documented that genomes which were dominant at a given time may be outcompeted by fitter mutants but may remain at memory levels [(111–113); reviewed in Refs. (114,115)]. The memory level in the mutant spectrum will generally be higher than the level that the same genome would occupy if its presence depended only of mutational pressure.
C) Genome segment reassortment. (D) Nonhomologous recombination. (E) Intracellular transposition or rearrangement of genetic material. ) that may remain as an episome or integrate into the cellular chromosome. (G) Gene transfers among distantly related cells (by cell-to-cell fusion, assimilation) may be a source of DNA variation. These and other forms of genetic variation and of transfer of genetic material among cells and subcellular replicons provide the molecular basis of the response of pathogens to selective forces, as discussed throughout this chapter.