By Howard M. Fillit MD, Alan W. O'Connell PhD

This prestigious quantity provides the findings of a world workforce of educational and biotechnological researchers. issues diversity from early detection courses concentrating on genetic elements, novel probes for detecting B-amyloid within the dwelling mind, and using telephonic screening and MRI's to the range of healing parts resembling antioxidants, estrogen agonists and diverse anti-B-amyloid and anti-tangle approaches.

The quantity continues to be an necessary source for the psychogeriatrician, psychiatrist, medical investigator, and neurobiologist, and a needs to for scientific libraries.

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Extra resources for Drug Discovery and Development for Alzheimer's Disease (2000)

Sample text

C he m The proposal presented in this chapter will provide intercenter reliability, sensitivity, and specificity on imaging assessment of hippocampal atrophy in 30 patients with mild cognitive impairment (MCI), 15 of whom are known to have incipient Alzheimer's disease (AD), based upon longitudinal follow-up compared with 30 elderly controls. Four imaging techniques will be assessed on a common data set derived from three centers (UCLA, the Mayo Clinic, and NYU). The following four techniques have been chosen based upon their demonstrated usefulness in evaluating medial temporal atrophy: 1.

Pearson correlation coefficients were calculated between the hippocampal volume measured from MRIs obtained at study entry, as well as the participants' baseline Alzheimer's Disease Assessment Scale-Cognitive portion (ADAS-COG) (Rosen, Mohs, & Davis, 1984) and Clinical Dementia Rating (CDR) Sum of Boxes (Morris, 1997), in order to determine the relationship between hippocampal volume and cognitive and functional performance at baseline. ht tp RESULTS Volumetric analyses have been performed on MRI scans obtained at the time of study entry from the first 77 participants enrolled in the MRI portion of the MCI protocol.

94 x . 1 (n = 80) age = 74 yr. edu = 15 yr. 6 yr. 3 yr. 5 yr. 6 yr. 51% female (n = 100) age = 75 yr. edu = 15 yr. 5 yr. 6 yr. 86 x . 86x1. 6 x. 8 yr. 9 yr. 63% female vn /fo ru Only 10 per group were enrolled from each center. c he m 4a ll. of the patients provided to them for hippocampal assessment. 5 T scanners across the world. 1 records the number of patients capable of being recruited from each site with the details of their scanning acquisition. Assessment methods. Four assessment techniques were implemented at each center.

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