By Howard M. Fillit MD
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Additional resources for Drug Discovery and Development for Alzheimer s Disease
C he m 4a ll. vn /fo ru m s/ in de x. ph p Consanguinity increases the prevalence in a population of autosomal recessive genes that may have undesirable characteristics. For example, an additional 1/16 of the variation of DNA is made homozygous by the inbreeding of a marriage of first-cousins. Conversely, the probability of identifying recessive or quasirecessive susceptibility factors is enhanced by inbreeding. 7, and children born to consanguineous unions have poorer health than the offspring of nonconsanguineous unions (including malignancies, congenital abnormalities, mental retardation, and physical handicap).
Note the mismatch of these averages in the Taliarach coordinate space. c he m 4a ll. vn /fo ru m s/ in de x. ph p individual patient's anatomy an average hippocampal 3-D model was resolved by averaging the vectorial displacements, on a point-by-point basis from the parametric mesh, for each patient's hippocampus. Hippocampal variability, expressed as a 3-D distance in the common coordinate space, was computed by taking the mean of the square roots of a 3-D displacement vector necessary to align each node along a patient's mesh onto the average representation of the population's hippocampus.
Twomey, C. , & Zinsmeister, A. R. (1990). MR-based volume measurements of the hippocampal formation and anterior temporal lobe: Validation studies. Radiology, 176, 205-209. Jack, C. , Petersen, R. , Xu, Y. , Waring, S. , O'Brien, P. , Tangalos, E. , Smith, G. , & Kokmen, E (1997). Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology, 49, 786-794. Jack, C. , Petersen, R. , Xu, Y. , O'Brien, P. , Smith, G. , Ivnik, R. , Boeve, B. F, Waring, S. , Tangalos, E.