By J. Djelmiš, G. Desoye, M. Ivaniševic, M. Porta, F.M. Matschinsky

Tendencies pointed out whilst estimating worldwide occurrence recommend the area is dealing with an epidemic of diabetes mellitus. for this reason a fast bring up within the occurrence of gestational diabetes mellitus is anticipated. This quantity presents a complete but concise review of the medical and medical features of gestational diabetes in addition to sort 1 and kind 2 diabetes mellitus while pregnant. through the booklet the authors undertake a multidisciplinary process and canopy elements corresponding to etiology, body structure, molecular biology and genetics, immunology, pathogenesis, analysis, therapy and administration, pathology and evidence-based drugs. The function of the placenta as a fetal organ on the interface among mom and fetus is roofed intensive. uncomplicated scientists and clinical researchers will locate numerous chapters reviewing the root of our realizing of many elements of the affliction starting from maternal endocrinology to fuel-mediated useful teratogenesis.

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Extra resources for Diabetology of Pregnancy (Frontiers in Diabetes)

Example text

J Clin Invest 1997;100:1775–1781. Herrera E, Knopp RH, Freinkel N: Carbohydrate metabolism in pregnancy. VI. Plasma fuels, insulin, liver composition, gluconeogenesis and nitrogen metabolism during gestation in the fed and fasted rat. J Clin Invest 1969;48:2260–2272. Herrera E: Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr 2000;54(suppl 1):S47–S51. Herrera E, Lasunción MA, Palacín M, Zorzano A, Bonet B: Intermediary metabolism in pregnancy.

10] FSIGT NM NM 40 NM NM (AIRg: 95) Kautzky-Willer et al. [11, 12] OGTT 62 78 ϩ(Ϫ) ϩ(ϩϩ) Ϯ(Ϫ) Bartha et al. [13] Insulin tolerance test 72 of NT 87 NM Insulin sensitivity and insulin secretion of pregnant women with GDM or NT in the third trimester given as percent of the mean insulin sensitivity of nonpregnant healthy controls or women with NT (reference group of each study). ϩ ϭ Increased; Ϫ ϭ decreased; Ϯ ϭ unchanged compared to controls; NM ϭ not measured; AIRg ϭ acute insulin response to glucose.

In that study cortisol further contributed to a variance in insulin sensitivity in lean and obese pregnant women. Leptin is an adipocyte-derived hormone that could be important in normal and in particular in diabetic pregnancies. It is supposed to regulate body weight through a negative feedback signal between adipose tissue and the hypothalamic center of satiety causing a decrease in food intake and an increase in energy expenditure and body temperature [20]. Furthermore, leptin is found to be higher in females than males and seems to be important for intact reproductive function.

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