By P. Giannakopoulos, P.R. Hof, J. Bogousslavsky

This book summarizes the newest advances in neurobiology, diagnostic ways and therapeutics of the foremost dementing health problems comparable to Alzheimer’s illness, frontotemporal dementia, Lewy physique ailment, and vascular dementia. In a succinct, functional and accomplished demeanour, it presents an up to date view of the problems prone to be encountered in an everyday perform. each one part is concentrated on a big type of dementia and is geared up following a similar scheme reviewing the pathophysiology of the illness, its diagnostic demanding situations, its attribute neuroimaging good points, healing interventions and sufferer administration concerns. fending off an overspecialized strategy, the publication bridges the distance among medical perform, complicated imaging, contemporary therapeutics and uncomplicated sciences. therefore, it serves as a great consultant for psychological overall healthiness execs operating within the box of dementia in addition to fundamental care physicians and scholars.

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Additional info for Dementia in Clinical Practice (Frontiers of Neurology and Neuroscience)

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The relevant question is whether functional imaging in MCI and in early AD could detect the progressive dysfunction and the neuropathological changes leading to dementia. Ideally, neuroimaging data should provide proofs of the functional impairment as well as the topography, intensity and type of the lesions. Indeed, a definite detection of the pathological substrate could theoretically confirm the diagnosis of AD or of other type of dementia. Because of the diversity of available imaging techniques, several approaches are possible, each one looking into particular aspects of the cerebral abnormalities causing the cognitive impairment.

Finally, indirect approaches focus on the detection of changes in serotonin or other neurotransmitter receptors as a result of cell death in hippocampus and entorhinal cortex. The density of serotonin receptors has been shown to increase in MCI as opposed to AD patients (upregulation), suggesting that compensatory mechanisms may exist at early stages of the degenerative process [30]. In conclusion, research efforts are needed to identify biomarkers with high specificity for each lesion type. With such biomarkers, the concept of MCI syndrome will be more restricted, since an accurate demonstration of the lesions would definitely posit the diagnosis of dementia.

In contrast, PIB studies in MCI patients are developing, delineating two groups of patients: those with low PIB binding, similar to controls, and those with high PIB binding, similar to AD patients [22]. Moreover, a follow-up study suggests that MCI patients converting to AD have high level PIB binding [23]. However, it is not yet clear whether the use of PIB will improve the diagnosis and prognosis of MCI patients. Indeed, PIB binding has also been reported in controls without dementia or MCI syndrome [24].

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