By Malak Kotb, Thierry Calandra

Univ. of Tennessee, Memphis. textual content offers a complete overview of cytokines and chemokines in immunity and human infectious ailments. Covers bacterial, viral, fungal, and parasitic infections. comprises an review of healing suggestions and brokers and the position in modulating host responses to pathogens and vaccines. DNLM: Chemokines--immunology.

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J. Clin. Nutr. 33, 13–16. 77. M. (1978) Immune response in the mutant diabetic C57BL/ Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays. J. Clin. Invest. 61, 243–250. 78. Mandel MA and Mahmoud AA. (1978) Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J. Immunol. 120, 1375–1377. Leptin 21 79. , and Mertin, J. (1979) Effects of the obese (ob/ob) genotype on spleen cell immune function. Int. Arch. Allergy. Appl. Immunol. 58, 121–127. 80. , and Kibrick, S.

Evaluation of candidate genomic markers for risk stratification of individuals at high risk of developing infectious disease has just begun. Many candidate genes still have to be studied and clinical significance of genomic markers will be tested. In addition, this new approach may prove to be a valuable inclusion criterion for studies testing the prevention of infectious diseases in subpopulations known to be at high risk because of genomic predisposition. Most studies so far include rather small numbers of individuals and are in danger of being statistically underpowered and lack quality control of genotyping.

J. Physiol. 273, R181–R186. 106. , and Sanchez-Margalet, V. (1999) Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol. 194, 6–11. 107. , Sion, B. P. (2001) Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action? J. Leukocyte Biol. 69, 414–418. 108. , et al. (1996) Leptin can induce proliferation, differentiation and functional activation of hemopoietic cells. Proc. Natl. Acad. Sci. USA 93, 14,564–14,568. 109. , Chicheportiche, R.

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