By Bernard Ravina; et al
''Translating laboratory discoveries into profitable therapeutics could be tough. medical Trials in Neurology goals to enhance the potency of medical trials and the advance of interventions in an effort to improve the advance of latest remedies for neurologic illnesses. It introduces the reader to the foremost suggestions underpinning trials within the neurosciences. This quantity tackles the demanding situations of developing cures for neurologic issues from size of brokers within the fearful method to the development of scientific symptoms via illustrating particular examine designs and their functions to diversified healing components. medical Trials in Neurology covers key matters in section I, II and III medical trials, in addition to post-marketing defense surveillance. issues addressed contain regulatory and implementation concerns, consequence measures and customary difficulties in drug improvement. Written through a multidisciplinary staff, this accomplished consultant is vital studying for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and scientific researchers within the pharmaceutical industry''-- Read more...
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Extra resources for Clinical trials in neurology : design, conduct, analysis
Some of these problems have arisen because we have historically used clinical scales that were developed to describe subgroups of domains afected by CNS diseases. One example is the EDSS in MS which is largely inluenced by lower extremity walking function, but less so by cognition or upper extremity function. Furthermore, it has been extremely diicult to determine and agree on what degree of change represents a clinically meaningful outcome. All of these factors have contributed to a high degree of failure in late stages of development (see Chapter 2).
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32. Weinmann O, Schnell L, Ghosh A, et al. Intrathecally infused antibodies against Nogo-A penetrate the CNS and downregulate the endogenous neurite growth inhibitor Nogo-A. Mol Cell Neurosci 2006; 32: 161–73. 33. Brooks DJ, Papapetropoulos S, Vandenhende F, et al. An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers. Clin Neuropharmacol 2010; 33: 55–60. 34. Finkel RS. Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124).