By Elias J. Anaissie, Michael R. McGinnis, Michael A. Pfaller

The 1st ebook of its sort to target the prognosis, prevention, and remedy of sufferers with fungal infections, this definitive reference returns in a totally revised, full-color re-creation. It provides particular concepts for figuring out, controlling, and fighting fungal infections dependent upon underlying rules of epidemiology and an infection keep an eye on coverage, pathogenesis, immunology, histopathology, and laboratory prognosis and antifungal treatment. greater than 560 photos, illustrations, and tables depict stipulations as they seem in genuine lifestyles and equip you to spot scientific manifestations with accuracy. elevated remedy content material is helping you enforce the main acceptable remedy quick, and an advantage CD-ROM-featuring all the photographs from the text-enables you to reinforce your digital presentations.

  • Includes particular ideas for diagnosing, combating, and treating fungal infections in numerous sufferer populations established upon underlying ideas of epidemiology and an infection keep an eye on coverage, pathogenesis, immunology, histopathology, and laboratory prognosis and antifungal therapy.
  • Covers etiologic brokers of ailment, fungal infections in specific hosts resembling pediatric sufferers and sufferers with melanoma and HIV, infections of particular organ platforms, and extra, to make you conscious of the distinctive issues considering sure situations.
  • good points clinically valuable and reader-friendly sensible tools-including algorithms, slides, graphs, pictorials, images, and radiographs-that larger illustrate and speak crucial issues, advertise effective use in a number of medical and educational settings, and facilitate slide making for lectures and presentations.
  • Offers a CD-ROM containing the entire book's photos to be used on your digital shows.

Note: The Kindle variation of this publication doesn't contain any CDs or DVDs.

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These fungi include: Blastomyces dermatitidis, Coccidioides immitis, Histoplasma capsulatum, Paracoccidioides brasiliensis, Sporothrix schenckii, and 25 S E C T I O N O N E General Principles, including Diagnosis Recent advances in understanding human opportunistic fungal pathogenesis mechanisms Penicillium marneffei. 134 In the environment, they pro-­ duce hyphae and conidia (likely the infectious propagule). Once inhaled by mammalian hosts, like Cryptococcus, these fungi persist in macrophages and establish latent infections.

Overexpression of the Candida albicans ALA1 gene in Saccharomyces cerevisiae results in aggregation following attachment of yeast cells to extracellular matrix proteins, adherence properties similar to those of Candida albicans. Loza L, et al. Functional analysis of the Candida albicans ALS1 gene product. Sheppard DC, et al. Functional and structural diversity in the Als protein family of Candida albicans. Schaller M, et al. Hydrolytic enzymes as virulence factors of Candida albicans. Schaller M, et al.

Zhao W, et al. Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitiv-­ ity to oxidative damage, and virulence. Langfelder K, et al. Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Langfelder K, et al. Biosynthesis of fungal melanins and their importance for human pathogenic fungi. Idnurm A, et al. Deciphering the model pathogenic fungus Cryptococcus neoformans.

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