By Vicki L. Schweickart, Carol J. Raport, David Chantry, Patrick W. Gray (auth.), Caroline A. Hébert PhD (eds.)

Caroline Hébert and a panel of key experimentalists and scientific investigators comprehensively assessment the cutting-edge within the chemokine box, starting from the consequences of chemokines and their receptors in retroviral infections, to their position in irritation, angiogenesis/angiostasis, and tumor phone biology. The publication examines intimately fifteen lately pointed out chemokines and elucidates the position of chemokine functionality in vivo from animal experiments. Animal types also are used to discover how chemokines function in various persistent and acute inflammatory illnesses and in noninflammatory procedures. a close overview of the rising function of chemokines in viral biology is additionally provided, with emphasis on HIV biology and novel healing percentages. Chemokines in sickness: Biology and medical examine summarizes the swiftly increasing wisdom of a blinding array of chemokines and offers clean insights into the advance of strong new medications for treating a large spectrum of diseases.

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43. , and Parmentier, M. (1996) Molecular cloning and chromosomal mapping of a novel human gene, ChemRl, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. Eur. J. Immunol. 26,3021-3028. 44. Raport, C. , Schweickart, V. , Eddy, R. , Shows, T. , and Gray, P. W. (1995) The orphan G protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tisues. Gene 163, 295-299. 16 Schweickart et al.

Rev. Immunol. 7, 145-173. 55. , and Nomiyama, H. (1997) Novellymphocyte-specific CCchemokines and their receptors. J. Leukoc. Bioi. 62, 634-644. 56. , and Yoshie, O. (1998) Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. J. Bioi. Chem. 273(12),7118-7122. 57. , and Yoshie, O. (1997) Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J. BioI. Chem. 272, 14,893-14,898. 58. Greaves, D. , Dairaghi, D. , Dieu, M.

40. , and Kieft, E. (1993) Epsetin-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67,2209-2220. 41. Schweickart, V. , Raport, C. , Byers, M. , Eddy, R. , Shows, T. , and Gray, P. W. 2. Genomics 23,643-650. 42. , Nista, A, Storlazzi, C. , and Santoni, A (1996) Molecular cloning ofTER1, a chemokine receptor-like gene expressed by lymphoid tissues. 1. Immunol. 157,2759-2763. 43. , and Parmentier, M. (1996) Molecular cloning and chromosomal mapping of a novel human gene, ChemRl, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor.

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