By Thomas E. Lane

Chemokines signify a relatives of over forty small proteins that, for the main half, are secreted into the surroundings and serve as by means of binding to G protein-coupled receptors (GPCRs) which are expressed on various diversified telephone varieties. while firstly pointed out just about 30 years in the past, those molecules have been linked to a variety of human inflammatory ailments and it used to be famous that expression can be imperative in leukocyte recruitment to infected tissue. inside a comparatively brief time period, early individuals in the box decided that those proteins displayed detailed and conserved structural positive factors and exerted powerful chemotactic results on outlined lymphocyte subsets. There are actually 4 sub-families of chemokines pointed out in accordance with outlined structural standards with regards to the positional place of conserved cysteine residues in the amino-terminus of the protein. Chemokines at the moment are well-known as very important in several organic approaches starting from protecting the organizational integrity of secondary lymphoid tissue to engaging in a variety of points of either innate and adaptive immune responses following microbial an infection.

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J Exp Med 184:963–969 50. Loh J, Chu DT, O’Guin AK, Yokoyama WM, Virgin IV HW (2005) Natural killer cells utilize both perforin and gamma interferon to regulate murine cytomegalovirus infection in the spleen and liver. J Virol 79:661–667 51. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ (1998) Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 187:601 52. Lucin P, Pavic I, Polic B, Jonjic S, Koszinowski UH (1992) Gamma interferondependent clearance of cytomegalovirus infection in salivary glands.

38 MCP-1 and Antiviral Defenses . . . . . . . . . . . . . . . . 38 6 Conclusions . . . . . . . . . . . . . . . . . . . . . . 38 34 34 35 36 References . . . . . . . . . . . . . . . . . . . . . . . . . 40 Abstract The complex interplays between cytokines and chemokines are emerging as key communication signals in the shaping of innate and adaptive immune responses against foreign pathogens, including viruses.

1 CCL2/MCP-1: The First Link . . . . . . . . . . . . . . . . 36 Resident Macrophages: MCP-1 Producers . . . . . . . . . . . . 1 MCP-1 and Macrophage Recruitment . . . . . . . . . . . . . 38 MCP-1 and Antiviral Defenses . . . . . . . . . . . . . . . . 38 6 Conclusions . . . . . . . . . . . . . . . . . . . . . . 38 34 34 35 36 References . . . . . . . . . . . . . . .

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