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Ultrathin cryosections of 7-day-old rat spinal cord stained with MAG antibodies and colloidal gold. MAG is detected in peri axonal membranes (A, arrowheads) in endosomes (A, arrows) during early stages of axonal ensheathment. During active stages of myelination, MAG is enriched in endosomes (B. arrow s). and distributed diffusel y in oli godendrocyte processes (B ,arrowheads) which extend to myelin internodes. In oligodendrocyte perinucl ear cytoplasm, MAG is also enriched in endosomes (c. arrows) and Golgi membranes (c.

Opin. Neurobiol. 5:588-595 Frail DE, Webster Hd. Braun PE (1985) Developmental expression of the myelin-associated glycoprotein in the peripheral nervous system is different from that in the central nervous system. 1. Neurochem. 45: I 308-1 3 10 Fruttiger M. Montag D, Schachner M. Martini R (1995) Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur. J. Neurosci. 7:511-515 Johnson PW. Abramow-Newerly W, Seilheimer B, Sadoul R, Tropak M8. Arquint M.

1996). Although little is known about the molecular interactions which regulate myelin's trophic effect on the maturation ofaxons, MAG is an attractive candidate. , 1994; Li et a!. 1994) and evidence that MAG can inhibit axonal regeneration (Mukhopadhyay et a!. 1994; McKerracher et al. 1994; Schafer et al. 1996) raise the possibility that MAG functions as a ligand that affects axonal properties. , submitted for publication). Myelin-Associated Glycoprotein 3S SUMMARY This chapter has reviewed much of the present literature regarding the possible function of MAG.

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