By Klaus J. Zülch M.D., Dr. h.c. (auth.)

The 3rd American version has been thoroughly revised and extended, even though elements of the textual content of the second one variation were integrated. I desire to recognize once more the wonderful translation of the previous versions by means of Dr. ALAN B. ROTHBALLER and the overdue Dr. JERZY OLSZEWSKI. With this version i've got the overall topic of the unique German variation released in 1951. in spite of the fact that, i've got attempted to think about smooth concepts and the various new courses almost about mind tumors. in the meantime, an early wish of mine has been fulfilled through the finishing touch and book of a category which are understood around the world and with a bit of luck be used extensively, particularly, the classi­ fication of the area wellbeing and fitness association: Histological Typing of Tu­ mours of the imperative fearful procedure (1979). The category which I utilized in the 1951 variation is especially on the subject of the ultimate development of that approved through the area future health association (WHO), due to the fact either keep on with the road of the BAILEY and CUSHING classifica­ tion of 1926/1930. To consolidate our previous strategies and stories we now have reclassi­ fied our selection of 9000 instances with the help of my co-workers Dr. M. FUKUI, Dr. A. SATO. Dr. E. SCHARRER, Dr. E. SIMON, and Dr. J. SZYMAS. within the final decade huge atlases were released, one referred to as an Atlas of the Histology of mind Tumors 1 (in six languages) and a moment one referred to as an Atlas of the Gross Neurosurgical Pathology 2.

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7). The same assumption later formed the basis of the meticulous work of BAILEY and CUSHING (1926, 1930) at the time when neurosurgery was developing into a modern specialty. Bailey's efforts led to a most refined system of classification and prognosis. This was necessary since VIRCHOW'S (1847, 1863/65) gross subdivision of tumors in the more "benign" (psammomas and gliomas) and the "malignant" (sarcomas and gliosarcomas) still existed, and was no longer adequate for clinical purposes. A finer classification was possible because the glia had already been subdivided following the research of the German and Spanish anatomical schools and particular types of gliomas had been correspondingly described (see ZULCH 1962a, Fig.

KERNOHAN and SAYRE (1952) also believed that there is a continual series of gradations extending from fibrillary and protoplasmic astrocytomas through astroblastomas to glioblastomas, and that a comparable series of stages might be demonstrated for oligodendrogliomas, ependymomas, and other tumor types, although they never worked the latter out in sufficient detail for every group. Their system reads as follows: New Names Old Names (with new names in parentheses) Astrocytoma grades 1--4 Astrocytoma (astrocytoma grade I) Astroblastoma (astrocytoma grade II) Spongioblastoma polare (left out) Glioblastoma multiforme (astrocytoma grades III and IV) Ependymoma (ependymoma grade I) Ependymoblastoma (ependymoma grades II-IV) Neuroepithelioma (left out) Medulloepithelioma (ependymoma grade IV) Oligodendroglioma (oligodendroglioma grades I-IV) Oligodendroblastoma (oligodendroglioma grades II-IV) Neurocytoma Ganglioneuroma (neuroastrocytoma grade I) Gangliocytoma Ganglioglioma Neuroblastoma Spongioneuroblastoma (neuroastrocytoma grades II-IV) Glioneuroblastoma Medulloblastoma Ependymoma grades 1--4 Oligodendroglioma grades 1--4 Neuroastrocytoma Medulloblastoma A detailed discussion of Kernohan's proposed classification appears in the section on grading of individual tumor types (p.

207, 289, 418). 4. Moreover, pinealoma cells in the CNS resemble exactly the cell type described by Del Rio Hortega (see RIVERSON and ZULCH 1979, Figs. 3, 4). 5. The pinealoma has a strong tendency to calcify completely, a characteristic feature unknown for the germinoma elsewhere in the body. 6. Finally, there are immunohistochemical indications, that the large cell is a pineal parenchyma cell (MATSUTANI 1976). Tumors of Neuroepithelial Tissue (for detailed description see Chap. 15) Astrocytic Tumors 1.

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