By Hiroshi Mitsumoto MD

This crucial ebook covers each element of residing with ALS, from scientific gains of the disorder to an summary of symptom administration to figuring out its prognosis. significant sections take care of overseeing remedy and rehabilitation, residing with ALS, the disease’s complicated section, end-of-life matters, and assets. greatly revised and rewritten, this variation includes new chapters at the most recent methods to treating ALS signs, using noninvasive ventilators, multidisciplinary workforce care, new instructions being constructed through the yankee Academy of Neurology for sufferers with ALS, using riluzole (Rilutek), and extra.

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Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology. 1996;47:1383–1388. 70. Schwarz GA, King G. Neuromuscular diseases of later maturity. Part 1. Geriatrics. 1955;10:197–207. 71. Brooks BR, Miller RG, Swash M, et al. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. ALS Other Motor Neuron Disord. 2000;1:293– 299. 2 The Clinical Features and Prognosis of Amyotrophic Lateral Sclerosis Hiroshi Mitsumoto The human brain has billions of nerve cells, or neurons.

Gurney ME, Cutting FB, Zhai P, et al. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol. 1996;39:147– 157. 67. Ascherio A, Weisskopf MG, O’Reilly EJ, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis. Ann Neurol. 2005;57:104–110. 68. Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med. 1994;330:585–591. 69. Miller RG, Moore D, Young LA, et al.

Nat Genet. 2008;40:29–31. 57. Cronin S, Berger S, Ding J, et al. A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet. 2008;17:768–774. 58. Corcia P, Mayeux-Portas V, Khoris J, et al. Abnormal SMN1 gene copy number is a susceptibility factor for amyotrophic lateral sclerosis. Ann Neurology. 2002;51:243– 246. 59. Corcia P, Camu W, Halimi JM, et al. SMN1 gene, but not SMN2, is a risk factor for sporadic ALS. Neurology. 2006;67:1147–1150. 60. Mackenzie IR, Bigio EH, Ince PG, et al.

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