By Philip Scheltens MD PhD, Serge Gauthier, Philip Scheltens, Jeffrey L. Cummings

content material: Innervation of Senile Plaques: A hyperlink among Amyloid and Neurofibrillary Pathology? B. Delatour, V. Blanchard, L. Pradier, and C. Duyckaerts Vascular elements and Alzheimer's affliction, I. Skoog, D. Gustafson, and M. Sjogren The function of White topic Lesions in Dementia, L. Pantoni Subclassification of light Cognitive Impairment in learn and medical perform, S. Gauthier and J. Touchon Neuropsychiatric elements of gentle Cognitive Impairment, T.J. Hung and J.L. Cummings Cognitive Rehabilitation in light Cognitive Impairment and Prodromal Alzheimer's affliction, M. van der Linden, A.-C. Juillerat, and X. Delbeuck medical Trial layout within the Age of Dementia remedies: demanding situations and possibilities, E. Mohr, C.L. Barclay, R. Anderson, and J. consistent Ethics of analysis in Dementia, J. Karlawish Memantine: A Glutamate Antagonist for therapy of Alzheimer's ailment, R. Smith Doody, B. Winbald, and V. Jelic administration of Comorbidity in Alzheimer's sickness, R. Jones dietary Prevention in Alzheimer's sickness, O. Guerin and B. Vellas Index

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Risk stratification in hypertension: new insights from the Framingham Study. Am J Hypertens 2000; 13(1 Pt 2):3S-10S. Kalmijn S, Foley D, White L et al. Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men: the Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol 2000; 20:2255–2260. Kuusisto J, Koivisto K, Mykkanen L et al. Association between features of the insulin resistance syndrome and Alzheimer’s disease independently of apolipoprotein E4 phenotype: cross-sectional population-based study.

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models. Proc Natl Acad Sci USA 1999; 96:3228–3233. Dodart JC, Mathis C, Saura J et al. Neuroanatomical abnormalities in behaviorally characterized APP (V717F) transgenic mice. Neurobiol Dis 2000; 7: 71–85. Gordon MN, King DL, Diamond DM et al. Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice. Neurobiol Aging 2001; 22:377–385. Koo EH, Sisodia SS, Archer DR et al. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

Vermeer SE, Den Heijer T, Koudstaal PJ et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke 2003; 34: 392–396. Pasquier F, Leys D. Why are stroke patients prone to develop dementia? J Neurol 1997; 244:135–142. Wetterling T, Kanitz R-D, Borgis K-J. Comparison of different diagnostic criteria for vascular dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN). Stroke 1996; 27:30–36. Amar K, Wilcock G, Scott M. The diagnosis of vascular dementia in the light of the new criteria.

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