By Nozomu Mori, Inhee Mook-Jung

This e-book brings jointly the main up to date info on contemporary learn result of major laboratories on getting older technological know-how in East Asia, rather in Japan, Korea, and Hong Kong. beginning with a complete review of varied hypotheses on organic mechanisms of getting older by means of Dr. Sataro Goto, each one bankruptcy covers large features of the newest findings in aging-related subject matters: centenarian reviews and genome research of progeria, metabolic biochemistry and neurobiology, toughness controls in yeast and nematodes, oxidative tension and calorie limit, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s ailments, with extra strength healing techniques to those age-related neurodegenerative illnesses. additionally incorporated, partly, is a precis and the results of a systematic dialogue discussion board known as the Asian getting older center for toughness (AACL) that has been held every year alternating among Japan and Korea over the last decade. This ebook can function an invaluable source for locating acceptable collaborators within the parts it covers. the objective readership is made of graduate scholars and researchers at universities, scientific and/or life-science faculties, and biomedical and pharmaceutical institutes.

Why does getting older exist? How can we age? How is every one organism’s lifespan decided? those are primary questions within the box. We can be nonetheless faraway from attaining an entire view of getting older mechanisms, yet this ebook, Aging Mechanisms, deals a superb chance to familiarize yourself with the main up-to-date growth within the biomedical study of getting older in Japan and Korea, the 2 best international locations for human longevity.

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The chemistry of modifications has been studied extensively, proving that the sidechains of specific amino acid residues, such as lysine and arginine, are modified (Stadtman 1993). Notably, carbonyl moieties generated by oxidation have most frequently been used to evaluate oxidative stress on proteins by biochemical or immunochemical methods (Levine et al. 1990; Nakamura and Goto 1996), although this method is not without problems (Fedorova et al. 2014; Goto and Nakamura 1997). In addition to a correlative relationship between the oxidative modification of proteins and aging, a causal relationship between age-related increases in oxidative stress and functional decline has been suggested (Martin et al.

This idea, called the dysdifferentiation theory of aging, was based on the finding that the expression of globin or its related mRNA and murine leukemia virus RNA is increased in the brains and livers of aged mice compared to their younger counterparts (Ono and Cutler 1978). More recently, it has been shown that 20 S. Goto gene expression is more heterogeneous in the tissues of individuals with advanced aging, including the cerebral cortex and rat hippocampus. These findings are compatible with the dysdifferentiation theory of aging (Somel et al.

Introduction One of the most striking features of modern society is the steady increase in life expectancy, accompanied by the rapid growth of the “oldest old” population, such as centenarians, those who reach the age of 100 years (Oeppen and Vaupel 2002; Vaupel 2010). Centenarians are virtually delayed or even escaped from life threatening diseases such as cardiovascular disease or cancers until the very late life, thus provide models for healthy aging (Perls 1995). During the recent two decades, the number of centenarian studies has appreciably increased, expanding our knowledge of biomedical and genetic underpinnings as well as psychosocial correlates of healthy longevity.

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