By Joseph F. Albright
George Washington Univ. tuition of medication, Washington, D.C. Examines the main positive factors and capabilities of the immune process probably to be altered via the getting older strategy. reviews the slow breakdown of the resistance to an infection within the elderly and discusses lifespan extension and dietary hold up of immunosenescence. DNLM: Immunity--Aged.
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These domains include: an N-terminal lectin domain that binds sialic acid and is required for hemagglutination; a lectin domain for ciliated host cells; a domain containing an arginine-glycine-asparagine (RGD) sequence that binds to the leukocyte integrin CR3 (CD11b/CD18) and two regions that resemble sites on factor X of the coagulation mechanism that also bind to leukocyte CR3 (33). This complexity allows FHA to interact with a variety of receptors on host ciliated cells, erythrocytes, and leukocytes.
Whether or not this occurs depends on a number of factors including the quantity and rate of formation of mucous. The wide variety of glycoconjugates with which bacterial lectins interact is shown in Table 2-4. That variety ensures the ability of many enteric bacteria to adhere at optimum sites and niches within the intestine. Intestinal E. coli strains can be categorized into several types depending on their attachment and invasive properties. Those categorized as enteropathogenic E. coli (EPEC) adhere to gut epithelial cells through intimin molecules.
Electron microscopy showed that the structure resembles a long hollow tube attached to a cylindrical base that anchors the structure to the bacterial inner and outer membranes. Other bacteria may induce the formation of pedestals or cuplike structures between themselves and host cells. The formation of such structures is initiated upon contact and association of bacterium and host cells facilitated by adhesion molecules. , actin, α-actinin, talin). Those cytoskeletal rearrangements result in effacement, which includes loss of microvilli and the resulting diarrhea.