By Institute of Medicine, Medical Follow-Up Agency, Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science, Laura B. Sivitz, Rick Erdtmann

Provides a record from the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies recommending study to shut major gaps in current wisdom of prion ailments and methods for strengthening the U.S. study infrastructure for learning those ailments. Softcover. DNLM: Prion ailments, prevention & control--United States.

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Extra resources for Advancing Prion Science: Guidance for the National Prion Research Program

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Brown P. 2001. Creutzfeldt-Jakob disease: blood infectivity and screening tests. Seminars in Hematology 38(4 Supplement 9):2–6. Brown P. 2002. Drug therapy in human and experimental transmissible spongiform encephalopathy. Neurology 58(12):1720–1725. Brown P, Cervenakova L, McShane LM, Barber P, Rubenstein R, Drohan WN. 1999. Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit CreutzfeldtJakob disease in humans.

1:3 Fund basic research to elucidate (1) the structural features of prions, (2) the molecular mechanisms of prion replication, (3) the mechanisms of pathogenesis of transmissible spongiform encephalopathies, and (4) the physiological function of PrPC. The committee believes basic research in these four areas will supply the knowledge required to advance TSE diagnostics more quickly than applied research alone. The report text describes specific gaps in knowledge that need to be filled in each of the four areas.

It includes an updated version of the material from the first report, with an additional chapter on the unique challenges of detecting TSE infectivity in blood. This summary presents the committee’s conclusions and recommendations, which are also listed in Table S-1. Clearly, we believe all the recommendations in this report are important. Given that NPRP has a limited amount of resources, however, it can act only on a limited number of recommendations each fiscal year. Therefore, we prioritized our recommendations by placing them in one of three ranks, 1 being the highest (see Table S-1).

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