By Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)
The objective of this publication is to supply the objective viewers, particularly scholars of drugs, Biology, structures Biology and Bioinformatics, in addition to skilled researchers in learn fields correct to metabolic syndrome (MetS) with an summary of the demanding situations and possibilities in platforms biology and the way it may be used to take on MetS. specifically, the goals are: (1) to supply an creation to the most important organic techniques fascinated with the pathophysiology of MetS; (2) by utilizing particular examples, offer an creation to the newest applied sciences that use a platforms biology method of research MetS; and (3) to offer an summary of the mathematical modeling ways for learning MetS.
The essentially written chapters by way of best specialists within the box offers targeted descriptions an important for the original place of this publication and its specialize in the appliance of structures biology to take on particular pathophysiologically appropriate features of MetS and offers a important functional consultant to this examine community.
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Extra resources for A Systems Biology Approach to Study Metabolic Syndrome
Not all metabolic functions can be conceptualized at the network level, however. For example, lipids are key building blocks of cellular membranes and lipoprotein particles. Changes of lipid levels in these structures lead to changes in their biophysical properties and thus also potentially affecting their function. While network-based modeling involves statistical inference as dependent on the network structure, 22 M. , molecular dynamics simulations. As an example of such approach, recent study has shown that adipose tissue in obesity is characterized by enrichment of specific ether phospholipids containing arachidonic acid, despite the lower dietary intake of polyunsaturated fatty acids (Pietiläinen et al.
2002). When compared to general population, NAFLD is associated to a five times higher mortality and morbidity, with an increased risk for CVD (Hamaguchi et al. 2007; Matteoni et al. 1999; Musunuru 2010). In a simplistic way of thinking, NAFLD can be considered the hepatic manifestation of the MetS, since both MetS and NAFLD originate from the combination of modern diet, lifestyle, and socio-economic factors. Over-nutrition, cheap high-energy food, and sedentary habits represent the starting point of the pathogenetic mechanisms involved in hepatic lipids accumulation, and in both hepatic and whole body IR (Bugianesi et al.
Dietary fat and cholesterol are directly absorbed into intestinal cells and incorporated in chylomicrons, which are secreted into bloodstream and then into capillaries of several tissues, such as adipose tissue and skeletal muscle. The TGs content of chylomicrons and circulating VLDL is reduced by the action of lipoprotein lipase (LPL, the rate-limiting step of tissue circulating TG uptake), thus leading to the formation of chylomicrons remnants and LDL enriched in cholesterol (Westerbacka et al.